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However, LVRS was favored compared with control groups in long-term mortality (overall response [OR] 0.76, 95% CI 0.61-0.95)

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Additionally, anxiety and stress trigger SNS hyperactivity, increasing renin release and angiotensin II, which promote renal vasoconstriction and tubulointerstitial damage (Wang and Dong, 2016) while elevated norepinephrine levels under mental distress accelerating kidney function decline (Tidgren and Hjemdahl, 1989)

Blood 88(3):10521061 Douer D, Tallman MS (2005) Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies